One bottle in the tank before your oil change. (A fair amount of the fuel additive, a big and heavy molecule gets in your oil. You're better off not having it in the oil for the oil change, so do it just before your oil change.)
Look for "complete fuel system cleaners," not "fuel injection cleaners" or "carburetor cleaner," etc. There is little difference in the type of additive, only in how much is in the bottle. The "complete" or "total" cleaners have the most. Same with 4 or 6 or 8 cylinder versions- guess what the difference is?
Techron, STP, CD-2 total/complete fuel system cleaners are all good ones.