JD:
Ideal for hp and ideal for safety are far different. In a perfect world, 12.2 is where nitrous derives the most power, but, virtually everyone tries for 10:5 to 11.0 for reliability, no different than the SC crowd trying to stay rich.
The 10:5 scares me because of the issues with fuel accumulation between rings. The reason is, most nitrous cars run richer near the end of the quarter due to the bottle pressure dropping, therefore, a car that starts at 10.5 ends up with an a/f in the 9's. This is more pronounced as the shot size increases. It may not be a big issue on a 150-200 shot, but, at 250-300 it is a big problem.
I wonder how many failures have been due to over-rich a/f when on nitrous. As stated previously, virtually every nitrous forum has case examples of over-rich causing that issue, on the other hand there are more examples of problems when running lean. I guess you have to walk the line and shoot for an average of 11.0.