What would be the main difference with going with a top fed injector vs having extra injectors before the throttle bodies? Any advantages verses disadvantages?
I assume you mean what are the advantages of replacing all 10, versus just adding a few at the TB? There are "top feed" and "side feed" injectors, which just refers to where on the injector body the fuel enters (ie where it sits in the rail).
Without serious investigation into the best location for extra injectors, I think you may come up with distribution problems for the fuel from the extras. It's a long way from the TB to the back cylinders.. better be sure the fuel goes back there. With bigger injectors at each cylinder, I would be more confident of uniform distribution. Of course, 10 injectors = $$$$, unless you can find suitable used units from other vehicles. Also, you can control the extra injectors with a smaller standalone unit, where the larger injectors would need some kind of work on the ecu.